Mechanism study of anti-influenza effects of Radix Isatidis water extract by red blood cells capillary electrophoresis
OBJECTIVE: To research the mechanism of the inhibition effects of BWE on cell attachment of influenza virus by capillary electrophoresis.
METHOD: The morphologic difference of red cells after treating with BWE [Radix Isatidis Extract] infected by influenza virus was detected with microscope, capillary electrophoresis and HA.
RESULT: The pretreatment of the normal cells with BWE inhibited the attachment of influenza to the cells, while no meaningful inhibition was observed when influenza virus was pretreated before being inoculated to cells. CONCLUSION: The results indicate that the inhibition effects of BWE on cell attachment of influenza virus may be an important mechanism of anti-influenza activity of Radix Isatidis Extracts.
PMID: 17225545
[Article in Chinese] Zhongguo Zhong Yao Za Zhi. 2006 Oct:31(20):1715-9. Chen ZW, Wu LW, Liu ST, Cai CP, Rao PF, Ke LJ.
Institute of Biotechnology, Fuzhou University, Fuzhou 350002, China. zerochen98@163.com
Comment:
Radix Isatidis is one of the most commonly used and studied anti-influenza virus herbs in Chinese medicine. This study indicates that an extract of the herb is capable of preventing the virus from attaching itself to cells, a mechanism that may assist in preventing spread of the virus.
