Researchers from The University of Texas at Austin have found that honeybees treated with a common antibiotic were half as likely to survive the week after treatment compared with untreated bees, a finding that may have health implications for bees and people alike.
The antibiotics cleared out beneficial gut bacteria in the bees, making a harmful pathogen, which also occurs in humans, to get a foothold.
The research is the latest discovery to indicate overuse of antibiotics can sometimes make living things, including people, sicker.
The UT Austin team found that after treatment with the common antibiotic tetracycline, the bees had dramatically fewer naturally occurring healthy gut microbes – bacteria that can help to block pathogens, break down toxins, promote absorption of nutrients from food and more. They also found elevated levels of a pathogenic bacterium, Serrate, that afflicts humans and other animals, in the bees treated with antibiotics, suggesting that the increased mortality might have been a result of losing the gut microbes that provide a natural defense against the dangerous bacteria.
The discovery has relevance for beekeepers and the agriculture industry. A decade ago, U.S. beekeepers began finding their hives decimated by what became known as colony collapse disorder. Millions of bees mysteriously disappeared, leaving farms with fewer pollinators for crops. Explanations for the phenomenon have included exposure to pesticides, habitat loss and bacterial infections, but the scientists now say antibiotics given to bees could also play a role.
“Our study suggests that perturbing the gut microbiome of honeybees is a factor, perhaps one of many, that could make them more susceptible to declining and to the colony collapsing,” Moran said. “Antibiotics may have been an underappreciated factor in colony collapse.”
Bees are a useful model for the human gut microbiome for several reasons. First, bees and humans both have a natural community of microbes in their guts, called a gut microbiome, which aids a number of functions including modulating behavior, development and immunity. Second, both have specialized gut bacteria – ones that live only in the host gut – that are passed from individual to individual during social interactions.
According to this study, overuse of antibiotics might increase the likelihood of infections from pathogens.
“We aren’t suggesting people stop using antibiotics,” Moran said. “Antibiotics save lives. We definitely need them. We just need to be careful how we use them.”
In large-scale U.S. agriculture, beekeepers typically apply antibiotics to their hives several times a year. The strategy aims to prevent bacterial infections that can lead to a widespread and destructive disease that afflicts bee larvae.
“It’s useful for beekeepers to use antibiotics to protect their hives from foulbrood,” said Raymann, referring to the disease. “But this work suggests that they should also consider how much and how often they’re treating hives.”
“This was just in bees, but possibly it’s doing the same thing to you when you take antibiotics,” Raymann said. “I think we need to be more careful about how we use antibiotics.”
Source: Kasie Raymann, Zack Shaffer, Nancy A. Moran. Antibiotic exposure perturbs the gut microbiota and elevates mortality in honeybees. PLOS Biology, 2017; 15 (3): e2001861 DOI: 10.1371/journal.pbio.2001861
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