Friday, September 18, 2020

Inhibiting Serotonin In Gut Could Cure Osteoporosis

An investigational drug that inhibits serotonin synthesis in the gut, administered orally once daily, effectively cured osteoporosis in mice and rats reports an international team led by researchers from Columbia University Medical Center, in the Feb. 7 issue of Nature Medicine. Serotonin in the gut has been shown in...

X-Rays Help Predict Permanent Bone Damage From Bisphosphonates

Breast cancer patients, individuals at risk for osteoporosis and those undergoing certain types of bone cancer therapies often take drugs containing bisphosphonates. These drugs have been found to place people at risk for developing osteonecrosis of the jaws (a rotting of the jaw bones). Dentists, as well as oncologists, are...

Value Of Drugs For Pre-Osteoporosis Exaggerated, Experts Warn

A series of recent scientific publications have exaggerated the benefits and underplayed the harms of drugs to treat pre-osteoporosis or "osteopenia" potentially encouraging treatment in millions of low risk women, warn experts in the British Medical Journal. The authors believe that this represents a classic...

Brain Controls Formation Of Bone, Researchers Find

The brain acts as a profound regulatory centre, controlling myriad processes throughout the body in ways we are only just beginning to understand. In new findings, Australian scientists have shown surprising connections between the brain and regulation of bone mass. One of the key functions of our skeletons is to provide mechanical...

New Evidence That Green Tea May Help Improve Bone Health

Researchers in Hong Kong are reporting new evidence that green tea — one of the most popular beverages consumed worldwide and now available as a dietary supplement — may help improve bone health. They found that the tea contains a group of chemicals that can stimulate bone formation and help slow its breakdown. The beverage ...

Roadmap Of Leptin Explains Its Regulation Of Bone And Appetite: New...

When the leptin-serotonin pathway is turned on in mice, the researchers found, appetite increases, the animals eat more, gain weight, and their bone mass increases. When the pathway is turned off, mice eat less, lose weight, and their bones weaken.

Roadmap Of Leptin Explains Its Regulation Of Bone And Appetite: New...

New research from Columbia University Medical Center has illuminated a previously unknown leptin-serotonin pathway in the brain that simultaneously promotes appetite and bone mass accrual. The research, which explains how leptin – well-known appetite-suppressing hormone – acts in the brain, is published in the Sept. 4 issue of Cell. When the leptin-serotonin pathway is turned ...

Research Highlights Salvia Root’s Benefit To Bone Growth

Osteogenic effects of D+beta-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) on osteoblasts and bone marrow stromal cells of intact and prednisone-treated rats. Cui L, Liu YY, Wu T, Ai CM, Chen HQ. Department of Pharmacology, Guangdong Medical College, Zhanjiang, China. cuiliao@163.com Acta Pharmacol Sin. 2009 Mar;30(3):321-32. AIM: Previous studies have shown that D(+)beta-3,4-dihydroxyphenyl lactic acid (salvianic acid ...

Scientists Uncover Immune System’s Role In Bone Loss

Got high cholesterol? You might want to consider a bone density test. A new UCLA study sheds light on the link between high cholesterol and osteoporosis and identifies a new way that the body’s immune cells play a role in bone loss. Published Aug. 20 in the journal Clinical Immunology, the research could lead to ...

Heartburn Drugs May Raise The Risk Of Hip Fractures

Even short-term use of popular acid-reducing heartburn drugs may raise the risk of hip fractures, U.S. researchers said on Monday. The increased risks appeared two years after patients started taking proton pump inhibitors such as Takeda Pharmaceutical Co’s Prevacid and histamine-2 receptor antagonists, or H2RAs, such as GlaxoSmithKline’s Zantac, researchers at Kaiser Permanente San Francisco ...

Osteoporosis Drugs Linked to Jaw Infection, Study Shows

A group of University of Southern California School of Dentistry researchers says it has identified the slimy culprits killing the jawbones of some people taking drugs that treat osteoporosis. Microbial biofilms, a mix of bacteria and sticky extracellular material, are causing jaw tissue infections in patients taking bisphosphonate drugs, said Parish Sedghizadeh, lead researcher and assistant ...

Common Oral Osteoporosis Drugs Linked To Serious Jaw Necrosis

Researchers at the University Of Southern California, School Of Dentistry release results of clinical data that links oral bisphosphonates to increased jaw necrosis. The study is among the first to acknowledge that even short-term use of common oral osteoporosis drugs may leave the jaw vulnerable to devastating necrosis, according to a new report. Osteoporosis currently affects ...