Thursday, April 25, 2024

Opinion: Misleading Drug Trials

Amgen’s incomplete report on an early major trial of epoetin misled the medical community about the anemia drug’s risks and benefits—and helped make Amgen rich.

Placebos Work — Even Without Deception

For most of us, the "placebo effect" is synonymous with the power of positive thinking; it works because you believe you're taking a real drug. But a new study rattles this assumption. Researchers at Harvard Medical School's Osher Research Center and Beth Israel Deaconess Medical Center (BIDMC) have found that placebos work even when administered without the seemingly requisite deception.

Natural Supplement, Echinacea, May Reduce Common-Cold Duration By Only Half A...

An over-the-counter herbal treatment believed to have medicinal benefits has minimal impact in relieving the common cold, according to research by the University of Wisconsin-Madison School of Medicine and Public Health. The study, published in this month's Annals of Internal Medicine, involved echinacea, a wild flower (also known as the purple coneflower) found in meadows and prairies of the Midwestern plains.

Study Finds Majority of Pharmaceutical Ads Do Not Adhere to FDA...

A study led by Mount Sinai School of Medicine researchers of 192 pharmaceutical advertisements in biomedical journals found that only 18 percent were compliant...

Majority Of Pharmaceutical Ads Do Not Adhere to FDA Guidelines, New...

A study led by Mount Sinai School of Medicine researchers of 192 pharmaceutical advertisements in biomedical journals found that only 18 percent were compliant with Food and Drug Administration (FDA) guidelines, and over half failed to quantify serious risks including death. The study, is published online August 18 in the journal Public Library of Science (PLoS) One.

No Standard For The Placebo?

Much of medicine is based on what is considered the strongest possible evidence: The placebo-controlled trial. A paper published in the October 19 issue of Annals of Internal Medicine -- entitled "What's In Placebos: Who Knows?" calls into question this foundation upon which much of medicine rests, by showing that there is no standard behind the standard -- no standard for the placebo.

Diagnostic ‘Fatal Flaws’ In The ICU May Account For As Many...

Each year as many as 40,500 critically ill U.S. hospital patients die with an unknown medical condition that may have caused or contributed to their death, Johns Hopkins patient safety experts report in a recent study. In a discussion of their findings, described online in BMJ Quality & Safety, researchers say that although diagnostic errors in the intensive care unit (ICU) may claim as many lives each year as breast cancer, they remain an underappreciated cause of preventable patient harm.