Calcium Dysregulation and Osteoporosis

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Part 2

By Jim English

Part 1 of Calcium Dysregulation and Osteoporosis addressed osteoporosis, a degenerative bone disorder responsible for over 1.5 million fractures annually in the United States. In addition to the physiology of bone remodeling, conventional treatments for osteoporosis, and health concerns surrounding calcium supplementation, Part 1 also discussed restoration of internal calcium regulation (homeostasis) with a special emphasis on a purified, biogenic marine material – nacre – that has been shown to restore calcium metabolism and support healthy bone formation.

In Part 2 we expand on the discussion of calcium homeostasis and review examples of individuals who have benefited from supplementation with a nutritional supplement formula that combines natural nacre with traditional bone-building Chinese herbs.

Restoring Calcium Balance

In addition to the studies in Part 1 describing nacre’s ability to stimulate new bone formation (osteogenesis), numerous contemporary findings support additional physiological benefits for bone health from a select group of traditional herbal compounds.

  • Oyster Shell (Concha Ostrea) is commonly used in traditional Chinese medicine for heart palpitations accompanied by anxiety, restlessness and insomnia. Additionally, oyster shell is used in reducing various types of swellings. Research in Japan and China indicates that both hydrolyzed and electrolyzed oyster shell increases calcium absorption and improves bone density.
  • Astragalus polysaccharides are potent immune modulators that are particularly valuable for restoring depressed immunity. Astragalus has been shown to partially reverse the damaging effects of prednisone (a potent steroid) in mice, which may account for its ability to counter the effects of chronic corticosteroid use on rates of osteoporosis formation (see Glucocorticoid-Induced Osteoporosis below).
    In post-menopausal women, as estrogen production slows down, osteoclast (bone dissolving) activity continues even as osteoblast (bone rebuilding) activity drops. This imbalance results in a dramatic loss of bone mass in women after their last menstrual period. Ovariectomy – surgical removal of the ovaries – also results in a decrease in bone tissue due to the loss of estrogen. Extracts of astragalus have been shown to reverse bone loss in ovariectomized lab animals, suggesting that this herb alone will likely contribute to the prevention of bone loss in post-menopausal women.
  • Angelica Sinensis is a traditional herb used to purify the blood and improve circulation. Angelica frequently appears as the main ingredient in Chinese herbal formulas for bone injuries. Aqueous extracts of Angelica sinensis have been found to directly stimulate bone marrow precursor cells to increase proliferation of mature osteoblasts and osteoclasts. Angelica sinensis extracts have also been shown to stimulate production of alkaline phosphatase (ALP), an enzyme secreted by osteoblasts in the process of forming new bone matrix. ALP, in turn, activates collagen fibers in such a way that they cause the deposition of calcium salts into the bone matrix (osteoid) to form hydroxyapatite. Blood serum levels of ALP are useful markers of bone formation and can aid in evaluating osteoporosis.
  • • Coix Seeds have been shown to lower blood sugar levels, reduce inflammation and counteract fibrosis formation. Coix seeds are included in bone-support formulas to aid in preventing further degeneration of bone and cartilage.

 

Clinical Benefits of Nacre-Herbal Formulas

Herbal nacre formulas have been shown to significantly reverse bone loss and enhance bone density, as determined by bone mineral density (BMD) measurements using DEXA (dual-energy x-ray absorptiometry) and Achilles (ultrasonometer) scans.

• Subject 1
The first subject, a 58-year-old female, enrolled in an early evaluation trial of an herbal nacre formula after a DEXA scan revealed osteopenia in her hips. The evaluation process involved taking 4 capsules of the herbal nacre formula daily. Eight months after the end of the evaluation – a full year after the beginning of the trial – a follow up bone scan revealed that her bone mass score had increased 6 percent (Fig. 1).

 

• Subject 2
The second subject, a 56-year-old female, also took part in an early evaluation trial after an Achilles scan revealed a baseline BMD score of 69. The subject received an herbal nacre formula for a period of four months. Two months after the end of the trial a follow-up Achilles scan revealed a BMD of 75, indicating a significant 10 percent improvement in bone density levels.

Fourteen months after the end of the evaluation trial, the subject underwent a follow-up scan to measure the potential residual effects of an herbal nacre formula. This third test revealed that her BMD had increased to 77, indicating a long-term restorative effect on calcium metabolism a full 16 months after her last dose.

Impressed with these results, the subject enrolled in a second, shorter trial to evaluate the efficacy of the herbal nacre formula in combination with another herbal formula for circulatory support.

After taking the two formulas for two months, a fourth bone density scan revealed a BMD score of 99, indicating bone density comparable to that of a healthy 30-year-old female. To confirm the test results, a second scan was ordered, this time resulting in a BMD of 100, well within the margin of error and confirmation of the previous score.

• Subject 3
At the age of 67, Waltraud H. was bedridden with spinal fractures caused by extreme osteoporosis. The year was 1998 and a DEXA bone scan of her left hip had just revealed that her bone density was only 25 percent that of a typical woman of her age. To make matters worse, her T-score of -6.2 indicated her bone density was lower than 99 percent of all women in her age group.

In June 2005, at the age of 74, Waltraud began taking an herbal nacre formula hoping to forestall any further loss in hip bone density. Three months later, after taking 2 capsules of the herbal nacre formula twice per day, a follow-up DEXA scan revealed a 12.3 percent improvement in hip bone density. Waltraud also reported that she was feeling stronger, was walking with greater ease, and was generally able to go about her day with much less pain than before

Waltraud continued taking the herbal nacre formula at a rate of three capsules per day. One year later, at age 75, another DEXA test scan indicated a significant gain, revealing an additional 22.4 percent increase in hipbone density. During this period Waltraud’s T-score also improved by 0.8 points.

Currently Waltraud retains 50 percent of the bone density of a woman her age, compared to seven years previously when it was down to 25 percent. While her bones are still brittle, her recent scores reflect a significant 30 to 40 percent reduction in her risk of suffering a severe fracture, according to data from a National Osteoporosis Risk Assessment study of 200,000 postmenopausal women.

By regulating how calcium is used in the body the herbal nacre formula was able to accomplish much more than just strengthening bones, as Waltraud attests in her recent letter. While others may not experience the same results as she did, her record of significant improvements as revealed by the DEXA scans illustrate that even those with very severe osteoporosis and brittle, fracture-prone bones may benefit from daily use of this unique herbal supplement.

• Subject 4
We recently reviewed several density scans from an 89-year-old man who began taking four capsules of an advanced herbal nacre formula daily back in July, 2006. After a second bone density test in June, 2007 he reduced his dosage to 2 capsules of the herbal nacre formula per day.

As the chart of his bone density scans shows (Table 1, above), just six months after beginning to take the herbal nacre formula his follow-up scan revealed a significant improvement of 5.6 percent in his lumbar spine and 9.6 percent in the femoral neck of his left hip bone. The radiologist reading the scan was impressed enough to add a handwritten note on the report – “marked improvement.”

The report itself indicates that he is moving out of osteoporosis towards osteopenia. We continue to receive reports of rapid improvement in bone density for elderly customers with significant bone loss [as in the case above.] It is remarkable to see such improvements for an older person with relatively healthy bone density, and very significant to see an established trend.

Glucocorticoid-Induced Osteoporosis

Steroid (glucocorticoid) drugs, such as prednisone, are well known to contribute to osteoporosis. Steroids speed up the rate at which bone is dissolved, and simultaneously slow the growth of new bone tissue, resulting in rapid and devastating bone loss. An average of 5% of bone mass is lost in the first year of steroid use. Consequently, fracture rates among patients on long-term steroid therapy range from 30-50%.

Preliminary studies in China have found that herbal formulas containing nacre can exert a preventive effect against glucocorticoid-induced osteoporosis, reducing calcium losses by 69%, while increasing bone density 27% and enhancing bone remodeling by 100%.

Nacre-Herbal Formulas and Avascular Necrosis of the Hip

Additionally, the combination of herbs and nacre is widely used in Chinese hospitals to treat Avascular Necrosis, a severe disorder related to osteoporosis. Avascular Necrosis disrupts circulation to the head of the femur, causing tissue death and the eventual collapse of the bone structure.

Researchers in Beijing treated 1,286 Avascular Necrosis patients, of which chronic steroid use was a predisposing factor for 669 (52%) of the patients. In clinical reports of treatment of the disorder with the herbal nacre formula, 90% of patients showed improvement in alleviating symptoms of pain and stiffness, and partial reversal of bone deterioration was observed by x-ray.

Next Issue: Calcium Dysregulation and Osteoporosis, Part 3, ConclusionUnderstanding DEXA bone density scores, accumulation of benefits over time, value of calcium supplements when taking an herbal nacre formula.

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