Daily Consumption of Coffee May Prevent Hardening of The Liver

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Chronic liver diseases rank as the 12th cause of death worldwide and is associated with unhealthy lifestyles. Conversely, a healthier lifestyle can help prevent or reverse liver disease. Liver-related mortality is closely related to the development of cirrhosis, the final consequence of progressive fibrosis, i.e. scarring of the liver resulting from chronic inflammation. According to a new study published in the Journal of Hepatology, researchers found that drinking coffee and herbal tea may protect against liver fibrosis, estimated as the degree of liver stiffness, which is high in extensive scarring of the liver. Because these beverages are popular, widely available, and inexpensive, they could have the potential to become important in the prevention of advanced liver disease.

“Over the past decades, we gradually deviated towards more unhealthy habits, including a sedentary lifestyle, decreased physical activity, and consumption of a ‘Happy Diet’,” explains lead author Louise J. M. Alferink, MD. “The Happy Diet, also known as the Western diet, is typically rich in unhealthy foods including processed foods lacking nutrients and artificial sugars. This has led not only to an obesity epidemic, but also to a rapid increase in the prevalence of non-alcoholic fatty liver disease (NAFLD), which is due to extensive accumulation of fat in the liver and resembles alcoholic liver disease in people who do not exceed two drinks a day of alcohol. In this context, examining accessible and inexpensive lifestyle strategies that have potential health benefits, such as coffee and tea consumption, is a viable approach to finding ways to halt the rapid increase of liver disease in developed countries.”

Epidemiological and experimental data suggest that coffee has health benefits on liver enzyme elevations, viral hepatitis, NAFLD, cirrhosis, and liver cancer.

Beyond the liver, coffee has been shown to be associated with lower overall mortality. While the exact mechanism is unknown it is thought that coffee exerts anti-oxidant effects.

Curious to find out whether coffee consumption would have a similar effect on liver stiffness in individuals without chronic liver disease the researchers gathered data on 2,424 participants 45 years or older living in a suburb of Rotterdam, The Netherlands. All participants underwent an extensive physical work-up to quantitatively measure liver stiffness. In addition, they completed an externally validated Food Frequency Questionnaire, which included detailed information on coffee and tea consumption.

Coffee and overall tea consumption was divided into three categories: none, moderate (0-3 cups per day), and frequent (more than 3 cups per day). Tea consumption was categorized by herbal, green, or black tea and further into none (0) or any (>0) consumption.

Investigators found that frequent coffee consumption was associated with significantly lower liver stiffness values (i.e. less scarring of the live), independent of lifestyle, metabolic, and environmental traits. They also found that both frequent coffee and any herbal tea consumption, even in small amounts, were significantly associated with lower liver stiffness values. Finally, while no direct association was found between either coffee or tea and the presence of fat accumulation in the liver (NAFLD) per se, the effect of coffee on lowering the liver stiffness was significant in both the group with and without liver fat.

The authors therefore concluded that frequent coffee and herbal tea seem to have beneficial effects on preventing liver scarring even before overt liver disease has developed.

However, some caution in the interpretation of the results is necessary. The study included only an elderly Caucasian population and there were few participants in the no-coffee or no-tea control groups, which limit a straightforward conclusion about the effect of coffee and tea on the liver.. The amount of tea consumed was generally low, making estimation of any protective effect difficult. Further, they note that more than 100 components are present in coffee and tea, including polyphenols and caffeine, which are contained in both beverages in very different and variable amounts.

Source: Louise J.M. Alferink, Juliana Fittipaldi, Jessica C. Kiefte-de Jong, et.al. Coffee and herbal tea consumption is associated with lower liver stiffness in the general population: The Rotterdam study. Journal of Hepatology, 2017; DOI: 10.1016/j.jhep.2017.03.013