Osteoporosis Research

Leptin -- commonly dubbed the "fat hormone" -- does more than tell the brain when to eat. A new study by researchers at The University of Akron and Northeast Ohio Medical University (NEOMED) shows that leptin may play a role in hearing and vision loss. This discovery, made in zebrafish treated to produce low leptin, could ultimately help doctors better understand sensory loss in humans.

Ultrasound can speed the healing of fractures. A randomized controlled trial reported in the open access journal BMC Musculoskeletal Disorders has found that the use of low-intensity pulsed ultrasound (LIPUS) in patients with tibial fractures which showed inadequate progress toward healing resulted in 34% greater bone mineral density (BMD) in the fracture area after 16 weeks than use of a sham device.

Even short-term use of popular acid-reducing heartburn drugs may raise the risk of hip fractures, U.S. researchers said on Monday. The increased risks appeared two years after patients started taking proton pump inhibitors such as Takeda Pharmaceutical Co’s Prevacid and histamine-2 receptor antagonists, or H2RAs, such as GlaxoSmithKline’s Zantac, researchers at Kaiser Permanente San Francisco ...

Beverages supplemented by whey-based protein can significantly reduce elevated blood pressure, reducing the risk of stroke and heart disease, a Washington State University study has found. Research led by nutritional biochemist Susan Fluegel and published in International Dairy Journal found that daily doses of commonly available whey brought a more than six-point reduction in the average blood pressure of men and women with elevated systolic and diastolic blood pressures.

Compounds in blueberries might turn out to have a powerful effect on formation of strong, healthy bones, if results from studies with laboratory rats turn out to hold true for humans.

When the leptin-serotonin pathway is turned on in mice, the researchers found, appetite increases, the animals eat more, gain weight, and their bone mass increases. When the pathway is turned off, mice eat less, lose weight, and their bones weaken.

Researchers at the University Of Southern California, School Of Dentistry release results of clinical data that links oral bisphosphonates to increased jaw necrosis. The study is among the first to acknowledge that even short-term use of common oral osteoporosis drugs may leave the jaw vulnerable to devastating necrosis, according to a new report. Osteoporosis currently affects ...

Calcium supplements, commonly taken by older people for osteoporosis, are associated with an increased risk of a heart attack, finds a study published online in the British Medical Journal. The results suggest that a reassessment of the role of calcium supplements in osteoporosis management is needed.

While simple falls, such as slipping while walking off a curb, may seem relatively harmless, they can actually lead to severe injury and death in elderly individuals, according to a new study published in The Journal of Trauma: Injury, Infection, and Critical Care.

An investigational drug that inhibits serotonin synthesis in the gut, administered orally once daily, effectively cured osteoporosis in mice and rats reports an international team led by researchers from Columbia University Medical Center, in the Feb. 7 issue of Nature Medicine. Serotonin in the gut has been shown in...

Breast cancer patients, individuals at risk for osteoporosis and those undergoing certain types of bone cancer therapies often take drugs containing bisphosphonates. These drugs have been found to place people at risk for developing osteonecrosis of the jaws (a rotting of the jaw bones). Dentists, as well as oncologists, are...

A new technique developed at Rensselaer Polytechnic Institute allows researchers to collect large amounts of biochemical information from nanoscale bone samples. Along with adding important new insights into the fight against osteoporosis, this innovation opens up an entirely new proteomics-based approach to analyzing bone quality. It could even aid the archeological and forensic study of human skeletons.