Sunday, July 13, 2025

New Genetic Regions Linked To Bone-Weakening Disease And Fractures

Thirty-two previously unidentified genetic regions associated with osteoporosis and fracture have been identified by a large, worldwide consortium of researchers, including Stanford Prevention Research Center chief John Ioannidis, MD, DSc. Variations in the DNA sequences in these regions confer either risk or protection from the bone-weakening disease. Many, but not all, of the regions encode proteins involved in pathways known to involve bone health.

Body Clock Regulates Metabolism, Study Shows

UC Irvine researchers have discovered that circadian rhythms – our own body clock – regulate energy levels in cells. The findings have far-reaching implications, from providing greater insights into the bond between the body's day-night patterns and metabolism to creating new ways to treat cancer, diabetes, obesity and a host of related diseases.

Scientists Redraw The Blueprint Of The Body’s Biological Clock

The discovery of a major gear in the biological clock that tells the body when to sleep and metabolize food may lead to new drugs to treat sleep problems and metabolic disorders, including diabetes. Scientists at the Salk Institute for Biological Studies, led by Ronald M. Evans, a professor in Salk's Gene Expression Laboratory, showed that two cellular switches found on the nucleus of mouse cells, known as REV-ERBα and REV-ERBβ, are essential for maintaining normal sleeping and eating cycles and for metabolism of nutrients from food.

Coordinating The Circadian Clock: Molecular Pair Controls Time-Keeping And Fat Metabolism

The 24-hour internal clock controls many aspects of human behavior and physiology, including sleep, blood pressure, and metabolism. Disruption in circadian rhythms leads to increased incidence of many diseases, including metabolic disease and cancer. Each cell of the body has its own internal timing mechanism, which is controlled by proteins that keep one another in check.

Sugar Production Switch In Liver May Offer Target For New Diabetes...

In their extraordinary quest to decode human metabolism, researchers at the Salk Institute for Biological Studies have discovered a pair of molecules that regulates the liver's production of glucose -- -- the simple sugar that is the source of energy in human cells and the central player in diabetes.

Big Pharma Whistles, And The Drug Enforcement Administration Comes Running

The DEA is enabling—even encouraging—a generation of opiate addicts, while the FDA tries to quash safe and helpful supplements like DHEA. Goodness, the legal drug-makers have been busy! This week the Associated Press revealed that in 2010, US pharmacies dispensed the equivalent of 69 tons of pure oxycodone (used as ingredient in OxyContin, Percocet, and Percodan) and 42 tons of pure hydrocodone (used in Vicodin, Norco, and Lortab). That’s enough to give forty 5-milligram Percocets and twenty-four 5-milligram Vicodins to every single person in the United States.

Potential Method To Control Obesity: Red Wine, Fruit Compound Could Help...

A compound found in red wine, grapes and other fruits, and similar in structure to resveratrol, is able to block cellular processes that allow fat cells to develop, opening a door to a potential method to control obesity, according to a Purdue University study.

Tai Chi Improves Arterial Compliance and Muscle Strength in Older Subjects

Older subjects who regularly practise Tai Chi were found to have better arterial compliance and greater muscle strength than non-practitioners. Exercise which can achieve both cardiovascular function and muscle strength "would be a preferred mode of training for older persons," say investigators.

Memory Declines Faster In Years Closest to Death; Mental Activity Best...

New research finds that a person's memory declines at a faster rate in the two- and-a-half years before death than at any other time after memory problems first begin. A second study shows that keeping mentally fit through board games or reading may be the best way to preserve memory during late life. Both studies are published in the April 4, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Eating Flavonoids Protects Men Against Parkinson’s Disease, Study Finds

Men who eat flavonoid-rich foods such as berries, tea, apples and red wine significantly reduce their risk of developing Parkinson's disease, according to new research by Harvard University and the University of East Anglia. Published April 4 in the journal Neurology®, the findings add to the growing body of evidence that regular consumption of some flavonoids can have a marked effect on human health.

Handheld Plasma Flashlight Rids Skin Of Notorious Pathogens

A group of Chinese and Australian scientists have developed a handheld, battery-powered plasma-producing device that can rid skin of bacteria in an instant. The device could be used in ambulance emergency calls, natural disaster sites, military combat operations and many other instances where treatment is required in remote locations.

Infection Linked To Dangerous Blood Clots In Veins and Lungs

Research shows iOlder adults who get infections of any kind -- such as urinary, skin, or respiratory tract infections -- are nearly three times more likely to be hospitalized for a dangerous blood clot in their deep veins or lungs, University of Michigan Health System research shows.